Concerning my and our work in Eurocentric academia, to rethink Transgender studies, trans* politics and activism in relation to decoloniality, the text focuses on body-politics, knowledge production and trans* imaginary in the context of crisis. This asks also for an analysis of the post-Cold War reconfiguration and multiplication of European borders, as my intention here is to shift the geography of reason, point to counter-genealogies of thought and to decolonial practices of resistance. This means to engage with decolonial critique in relation to the processes of colonial capitalist divisions and differentiation, when speaking about the coloniality of gender, as well as the global imposition of western Eurocentric feminist, queer and transgender knowledge.